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	Provedor de dados BJMBR (2) Autor Dal-Pizzol,F. (2) Moreira,J.C.F. (2) Barichello,T. (1) Bernard,E.A. (1) Constantino,L.S. (1) Ferreira,C.J.S. (1) Klamt,F. (1) Machado,R.A. (1) Martins,M.R. (1) Quevedo,J. (1) Reinke,A. (1) Ribeiro,N.C. (1) Rocha,A.B. (1) Valvassori,S.S. (1) Mais... Palavra-chave Cecal ligation and puncture (1) Cognitive impairment (1) Forced swimming test (1) High mobility group proteins (1) Histones (1) Phosphorylation (1) Plus-maze test (1) Recognition memory (1) Retinol (1) Sepsis survivors (1) Sertoli cells (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2007 (1) 2000 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Behavioral deficits in sepsis-surviving rats induced by cecal ligation and perforation BJMBR Barichello,T.; Martins,M.R.; Reinke,A.; Constantino,L.S.; Machado,R.A.; Valvassori,S.S.; Moreira,J.C.F.; Quevedo,J.; Dal-Pizzol,F.. Sepsis and its complications are the leading causes of mortality in intensive care units, accounting for 10-50% of deaths. Intensive care unit survivors present long-term cognitive impairment, including alterations in memory, attention, concentration, and/or global loss of cognitive function. In the present study, we investigated behavioral alterations in sepsis-surviving rats. One hundred and ten male Wistar rats (3-4 months, 250-300 g) were submitted to cecal ligation and puncture (CLP), and 44 were submitted to sham operation. Forty-four rats (40%) survived after CLP, and all sham-operated animals survived and were used as control. Twenty animals of each group were used in the object recognition task (10 in short-term memory and 10 in long-term memory),... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sepsis survivors; Recognition memory; Plus-maze test; Forced swimming test; Cecal ligation and puncture; Cognitive impairment. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000600013 Retinol-induced changes in the phosphorylation levels of histones and high mobility group proteins from Sertoli cells BJMBR Moreira,J.C.F.; Dal-Pizzol,F.; Rocha,A.B.; Klamt,F.; Ribeiro,N.C.; Ferreira,C.J.S.; Bernard,E.A.. Chromatin proteins play a role in the organization and functions of DNA. Covalent modifications of nuclear proteins modulate their interactions with DNA sequences and are probably one of the multiple factors involved in the process of switch on/off transcriptionally active regions of DNA. Histones and high mobility group proteins (HMG) are subject to many covalent modifications that may modulate their capacity to bind to DNA. We investigated the changes induced in the phosphorylation pattern of cultured Wistar rat Sertoli cell histones and high mobility group protein subfamilies exposed to 7 µM retinol for up to 48 h. In each experiment, 6 h before the end of the retinol treatment each culture flask received 370 KBq/ml [32P]-phosphate. The histone and HMGs... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sertoli cells; Phosphorylation; Histones; High mobility group proteins; Retinol. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000300005 Registros recuperados: 2 Primeira ... 1 ... Última

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